http://120.24.161.253:5617/index.php?action=history&feed=atom&title=%E8%82%9D%E8%B1%86%E7%8A%B6%E6%A0%B8%E5%8F%98%E6%80%A7-%E5%8F%91%E7%97%85%E9%83%A8%E4%BD%8D-%E8%82%9D%E8%84%8F 2026-05-12T05:27:03Z 本wiki的该页面的版本历史 MediaWiki 1.30.0 http://120.24.161.253:5617/index.php?title=%E8%82%9D%E8%B1%86%E7%8A%B6%E6%A0%B8%E5%8F%98%E6%80%A7-%E5%8F%91%E7%97%85%E9%83%A8%E4%BD%8D-%E8%82%9D%E8%84%8F&diff=2026978&oldid=prev 2026-04-16T04:37:21Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="1" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: white; color:black; text-align: center;">2026年4月16日 (四) 04:37的版本</td> </tr><tr><td colspan="2" style="text-align: center;" lang="zh-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

KGadmin http://120.24.161.253:5617/index.php?title=%E8%82%9D%E8%B1%86%E7%8A%B6%E6%A0%B8%E5%8F%98%E6%80%A7-%E5%8F%91%E7%97%85%E9%83%A8%E4%BD%8D-%E8%82%9D%E8%84%8F&diff=2010410&oldid=prev 2026-04-15T13:20:28Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2026年4月15日 (三) 13:20的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l5" >第5行：</td> <td colspan="2" class="diff-lineno">第5行：</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">妊娠期发病的肝豆状核变性一例</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">肝豆状核变性的诊治现状</ins>===</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">摘要 </del>[[肝豆状核变性]]<del class="diffchange diffchange-inline">(HLD )又称威尔逊病(WD) </del>,<del class="diffchange diffchange-inline">是一种常染色体隐性遗传病</del>,<del class="diffchange diffchange-inline">致病基因定位于染色体 13q14</del>.<del class="diffchange diffchange-inline">3 的ATP7B </del>,<del class="diffchange diffchange-inline">该基因突变导致 P型铜转运 ATP酶功能减弱或丧失</del>,<del class="diffchange diffchange-inline">导致血清铜蓝蛋白合成减少和胆道排铜障碍</del>,<del class="diffchange diffchange-inline">铜离子在</del>[[肝脏]]<del class="diffchange diffchange-inline">、脑、角膜、肾脏等部位沉积</del>,<del class="diffchange diffchange-inline">引起进行性加重的锥体外系症状、精神症状、肝硬化、肾功能损害及角膜色素环(</del>K-<del class="diffchange diffchange-inline">F环)</del>[<del class="diffchange diffchange-inline">1</del>] .<del class="diffchange diffchange-inline">妊娠期间发病患者罕见</del>,<del class="diffchange diffchange-inline">容易延误诊断.现报道一例孕期发病伴A T P7B基因双突变的病例</del>.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[肝豆状核变性]]<ins class="diffchange diffchange-inline">是常染色体隐性遗传的铜代谢障碍性疾病</ins>,<ins class="diffchange diffchange-inline">由于13号染色体上ATP7B基因突变</ins>,<ins class="diffchange diffchange-inline">导致其编码产物ATP7B的功能缺陷,引起铜在[[肝脏]]、脑、角膜、肾脏等病理性沉积,临床表现多样,最常见为肝病、神经系统疾病、角膜色素环</ins>.</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===128例肝豆状核变性分析===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">结论[[肝豆状核变性]]临床表现多样</ins>,<ins class="diffchange diffchange-inline">除了主要累及[[肝脏]]和神经系统外</ins>,<ins class="diffchange diffchange-inline">还可单纯累及肾脏或骨骼系统等</ins>,<ins class="diffchange diffchange-inline">给临床诊断带来困难.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===儿童肝豆状核变性19例临床分析===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">结论:[[肝豆状核变性]]临床表现多样,可累及</ins>[[肝脏]]<ins class="diffchange diffchange-inline">、神经、血液、骨骼、肾脏等多个系统,首诊时易误诊、漏诊</ins>,K-<ins class="diffchange diffchange-inline">F环、血清铜蓝蛋白、24 h尿铜测定及影像学手段综合考虑可有助于确诊本病.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===肝豆状核变性误诊研究===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">结论：</ins>[<ins class="diffchange diffchange-inline">[肝豆状核变性]]临床表现多样，除了[[肝脏]]和神经系统受累为主外，还可以单纯累及肾脏或骨骼系统等。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===儿童肝豆状核变性19例临床分析===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">结论 [[肝豆状核变性]]临床表现多样,除了主要累及[[肝脏]</ins>]<ins class="diffchange diffchange-inline">外,还可以累及神经系统、血液系统、肾脏、骨骼等,还可以表现为无症状,临床工作中应提高对本病的认识,结合辅助检查以及家族史及时正确诊断,及时治疗</ins>.</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===35例肝豆状核变性分析===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">结论 [[肝豆状核变性]]临床表现多样</ins>,<ins class="diffchange diffchange-inline">除了主要累及[[肝脏]]和神经系统外,还可累及肾脏和骨关节等,对于非典型病例临床诊断困难</ins>.</div></td></tr> </table>

KGadmin http://120.24.161.253:5617/index.php?title=%E8%82%9D%E8%B1%86%E7%8A%B6%E6%A0%B8%E5%8F%98%E6%80%A7-%E5%8F%91%E7%97%85%E9%83%A8%E4%BD%8D-%E8%82%9D%E8%84%8F&diff=2026977&oldid=prev 2026-04-13T13:56:59Z

<p>修改1</p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2026年4月13日 (一) 13:56的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l5" >第5行：</td> <td colspan="2" class="diff-lineno">第5行：</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">肝豆状核变性的诊治现状</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">妊娠期发病的肝豆状核变性一例</ins>===</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[肝豆状核变性]]<del class="diffchange diffchange-inline">是常染色体隐性遗传的铜代谢障碍性疾病</del>,<del class="diffchange diffchange-inline">由于13号染色体上ATP7B基因突变</del>,<del class="diffchange diffchange-inline">导致其编码产物ATP7B的功能缺陷,引起铜在[[肝脏]]、脑、角膜、肾脏等病理性沉积,临床表现多样,最常见为肝病、神经系统疾病、角膜色素环</del>.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">摘要 </ins>[[肝豆状核变性]]<ins class="diffchange diffchange-inline">(HLD )又称威尔逊病(WD) </ins>,<ins class="diffchange diffchange-inline">是一种常染色体隐性遗传病</ins>,<ins class="diffchange diffchange-inline">致病基因定位于染色体 13q14</ins>.<ins class="diffchange diffchange-inline">3 的ATP7B </ins>,<ins class="diffchange diffchange-inline">该基因突变导致 P型铜转运 ATP酶功能减弱或丧失</ins>,<ins class="diffchange diffchange-inline">导致血清铜蓝蛋白合成减少和胆道排铜障碍</ins>,<ins class="diffchange diffchange-inline">铜离子在</ins>[[肝脏]]<ins class="diffchange diffchange-inline">、脑、角膜、肾脏等部位沉积</ins>,<ins class="diffchange diffchange-inline">引起进行性加重的锥体外系症状、精神症状、肝硬化、肾功能损害及角膜色素环(</ins>K-<ins class="diffchange diffchange-inline">F环)</ins>[<ins class="diffchange diffchange-inline">1</ins>] <ins class="diffchange diffchange-inline">.妊娠期间发病患者罕见</ins>,<ins class="diffchange diffchange-inline">容易延误诊断</ins>.<ins class="diffchange diffchange-inline">现报道一例孕期发病伴A T P7B基因双突变的病例</ins>.</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===128例肝豆状核变性分析===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">结论[[肝豆状核变性]]临床表现多样</del>,<del class="diffchange diffchange-inline">除了主要累及[[肝脏]]和神经系统外</del>,<del class="diffchange diffchange-inline">还可单纯累及肾脏或骨骼系统等</del>,<del class="diffchange diffchange-inline">给临床诊断带来困难.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===儿童肝豆状核变性19例临床分析===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">结论:[[肝豆状核变性]]临床表现多样,可累及</del>[[肝脏]]<del class="diffchange diffchange-inline">、神经、血液、骨骼、肾脏等多个系统,首诊时易误诊、漏诊</del>,K-<del class="diffchange diffchange-inline">F环、血清铜蓝蛋白、24 h尿铜测定及影像学手段综合考虑可有助于确诊本病.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===肝豆状核变性误诊研究===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">结论：</del>[<del class="diffchange diffchange-inline">[肝豆状核变性</del>]<del class="diffchange diffchange-inline">]临床表现多样，除了[[肝脏]]和神经系统受累为主外，还可以单纯累及肾脏或骨骼系统等。</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===儿童肝豆状核变性19例临床分析===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">结论 [[肝豆状核变性]]临床表现多样,除了主要累及[[肝脏]]外,还可以累及神经系统、血液系统、肾脏、骨骼等,还可以表现为无症状</del>,<del class="diffchange diffchange-inline">临床工作中应提高对本病的认识,结合辅助检查以及家族史及时正确诊断,及时治疗</del>.</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===35例肝豆状核变性分析===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">结论 [[肝豆状核变性]]临床表现多样,除了主要累及[[肝脏]]和神经系统外,还可累及肾脏和骨关节等,对于非典型病例临床诊断困难</del>.</div></td><td colspan="2">&#160;</td></tr> </table>

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<p>修改1</p> <p><b>新页面</b></p><div>主实体：[[肝豆状核变性]]，关系：[[发病部位]] ，尾实体：[[肝脏]]<br /> <br /> ==关系介绍==<br /> 待补充<br /> <br /> ==来源==<br /> ===肝豆状核变性的诊治现状===<br /> [[肝豆状核变性]]是常染色体隐性遗传的铜代谢障碍性疾病,由于13号染色体上ATP7B基因突变,导致其编码产物ATP7B的功能缺陷,引起铜在[[肝脏]]、脑、角膜、肾脏等病理性沉积,临床表现多样,最常见为肝病、神经系统疾病、角膜色素环.<br /> <br /> ===128例肝豆状核变性分析===<br /> 结论[[肝豆状核变性]]临床表现多样,除了主要累及[[肝脏]]和神经系统外,还可单纯累及肾脏或骨骼系统等,给临床诊断带来困难.<br /> <br /> ===儿童肝豆状核变性19例临床分析===<br /> 结论:[[肝豆状核变性]]临床表现多样,可累及[[肝脏]]、神经、血液、骨骼、肾脏等多个系统,首诊时易误诊、漏诊,K-F环、血清铜蓝蛋白、24 h尿铜测定及影像学手段综合考虑可有助于确诊本病.<br /> <br /> ===肝豆状核变性误诊研究===<br /> 结论：[[肝豆状核变性]]临床表现多样，除了[[肝脏]]和神经系统受累为主外，还可以单纯累及肾脏或骨骼系统等。<br /> <br /> ===儿童肝豆状核变性19例临床分析===<br /> 结论 [[肝豆状核变性]]临床表现多样,除了主要累及[[肝脏]]外,还可以累及神经系统、血液系统、肾脏、骨骼等,还可以表现为无症状,临床工作中应提高对本病的认识,结合辅助检查以及家族史及时正确诊断,及时治疗.<br /> <br /> ===35例肝豆状核变性分析===<br /> 结论 [[肝豆状核变性]]临床表现多样,除了主要累及[[肝脏]]和神经系统外,还可累及肾脏和骨关节等,对于非典型病例临床诊断困难.</div>

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