http://120.24.161.253:5617/index.php?action=history&feed=atom&title=%E7%BB%93%E8%8A%82%E6%80%A7%E7%A1%AC%E5%8C%96%E7%97%87-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E9%9B%B7%E5%B8%95%E9%9C%89%E7%B4%A0 2026-07-10T13:30:50Z 本wiki的该页面的版本历史 MediaWiki 1.30.0 http://120.24.161.253:5617/index.php?title=%E7%BB%93%E8%8A%82%E6%80%A7%E7%A1%AC%E5%8C%96%E7%97%87-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E9%9B%B7%E5%B8%95%E9%9C%89%E7%B4%A0&diff=2027782&oldid=prev 2026-04-16T04:37:44Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="1" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: white; color:black; text-align: center;">2026年4月16日 (四) 04:37的版本</td> </tr><tr><td colspan="2" style="text-align: center;" lang="zh-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

KGadmin http://120.24.161.253:5617/index.php?title=%E7%BB%93%E8%8A%82%E6%80%A7%E7%A1%AC%E5%8C%96%E7%97%87-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E9%9B%B7%E5%B8%95%E9%9C%89%E7%B4%A0&diff=2007378&oldid=prev 2026-04-15T13:16:59Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2026年4月15日 (三) 13:16的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l5" >第5行：</td> <td colspan="2" class="diff-lineno">第5行：</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">结节性硬化症合并肾血管平滑肌脂肪瘤22例临床分析</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">雷帕霉素治疗结节性硬化症合并婴儿痉挛症一例报告并文献复习</ins>===</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">近年来对[[结节性硬化症]]的遗传及分子生物学层面的研究进展使</del>[[雷帕霉素]]<del class="diffchange diffchange-inline">或依维莫司(everolimus)成为可选的药物治疗方法，正常状态下肿瘤抑制基因TSCl／TSC2编码的蛋白复合物可从上游抑制细胞生长调节因子mTOR的活性，</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">患者由于TSCl／TSC2突变使mTOR活性上调，促使细胞过度增殖，形成肿瘤样变[l2|。</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[雷帕霉素]]<ins class="diffchange diffchange-inline">治疗</ins>[[结节性硬化症]]<ins class="diffchange diffchange-inline">合并婴儿痉挛症一例报告并文献复习</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">儿童结节性硬化症合并癫(癎)临床特点分析</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">雷帕霉素治疗结节性硬化症合并婴儿痉挛症一例报告并文献复习===</ins></div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">近年来，由于明确了</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">致病性基因突变、揭示了mTOR信号转导通路过度激活的特异性意义，从而发现了可能逆转，甚至治愈</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">的靶点n“，主要药物包括传统的</del>[[雷帕霉素]]<del class="diffchange diffchange-inline">和新一代的依维奠司，均为治疗</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">的特异性药物。</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">目的 探讨[[雷帕霉素]]治疗[[结节性硬化症]]合并婴儿痉挛症的临床疗效.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===结节性硬化症长期误诊为癫痫1例并文献复习===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">结论 [[雷帕霉素]]治疗以癫痫为首发表现的[[结节性硬化症]],疗效确切.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===雷帕霉素对儿童结节性硬化症相关肾脏疾病的疗效观察</ins>===</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[[雷帕霉素]]对儿童</ins>[[结节性硬化症]]<ins class="diffchange diffchange-inline">相关肾脏疾病的疗效观察</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===雷帕霉素对儿童结节性硬化症相关肾脏疾病的疗效观察===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">目的 探讨[[雷帕霉素]]治疗</ins>[[结节性硬化症]]<ins class="diffchange diffchange-inline">(TSC)相关肾脏疾病患儿的疗效和安全性.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===雷帕霉素治疗结节性硬化症合并室管膜下巨细胞型星形细胞瘤四例报告及文献复习===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[雷帕霉素]]<ins class="diffchange diffchange-inline">治疗</ins>[[结节性硬化症]]<ins class="diffchange diffchange-inline">合并室管膜下巨细胞型星形细胞瘤四例报告及文献复习</ins></div></td></tr> </table>

KGadmin http://120.24.161.253:5617/index.php?title=%E7%BB%93%E8%8A%82%E6%80%A7%E7%A1%AC%E5%8C%96%E7%97%87-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E9%9B%B7%E5%B8%95%E9%9C%89%E7%B4%A0&diff=2027781&oldid=prev 2026-04-13T13:56:59Z

<p>修改1</p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2026年4月13日 (一) 13:56的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l5" >第5行：</td> <td colspan="2" class="diff-lineno">第5行：</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">雷帕霉素治疗结节性硬化症合并婴儿痉挛症一例报告并文献复习</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">结节性硬化症合并肾血管平滑肌脂肪瘤22例临床分析</ins>===</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[雷帕霉素]]<del class="diffchange diffchange-inline">治疗</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">合并婴儿痉挛症一例报告并文献复习</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">近年来对[[结节性硬化症]]的遗传及分子生物学层面的研究进展使</ins>[[雷帕霉素]]<ins class="diffchange diffchange-inline">或依维莫司(everolimus)成为可选的药物治疗方法，正常状态下肿瘤抑制基因TSCl／TSC2编码的蛋白复合物可从上游抑制细胞生长调节因子mTOR的活性，</ins>[[结节性硬化症]]<ins class="diffchange diffchange-inline">患者由于TSCl／TSC2突变使mTOR活性上调，促使细胞过度增殖，形成肿瘤样变[l2|。</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">雷帕霉素治疗结节性硬化症合并婴儿痉挛症一例报告并文献复习===</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">儿童结节性硬化症合并癫(癎)临床特点分析</ins>===</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; 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white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===雷帕霉素对儿童结节性硬化症相关肾脏疾病的疗效观察</del>===</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">[[雷帕霉素]]对儿童</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">相关肾脏疾病的疗效观察</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===雷帕霉素对儿童结节性硬化症相关肾脏疾病的疗效观察===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">目的 探讨[[雷帕霉素]]治疗</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">(TSC)相关肾脏疾病患儿的疗效和安全性.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">===雷帕霉素治疗结节性硬化症合并室管膜下巨细胞型星形细胞瘤四例报告及文献复习===</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[雷帕霉素]]<del class="diffchange diffchange-inline">治疗</del>[[结节性硬化症]]<del class="diffchange diffchange-inline">合并室管膜下巨细胞型星形细胞瘤四例报告及文献复习</del></div></td><td colspan="2">&#160;</td></tr> <!-- diff cache key mediawiki:diff:version:1.11a:oldid:2007377:newid:2027781 --> </table>

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<p>修改1</p> <p><b>新页面</b></p><div>主实体：[[结节性硬化症]]，关系：[[药物治疗]] ，尾实体：[[雷帕霉素]]<br /> <br /> ==关系介绍==<br /> 待补充<br /> <br /> ==来源==<br /> ===雷帕霉素治疗结节性硬化症合并婴儿痉挛症一例报告并文献复习===<br /> [[雷帕霉素]]治疗[[结节性硬化症]]合并婴儿痉挛症一例报告并文献复习<br /> <br /> ===雷帕霉素治疗结节性硬化症合并婴儿痉挛症一例报告并文献复习===<br /> 目的 探讨[[雷帕霉素]]治疗[[结节性硬化症]]合并婴儿痉挛症的临床疗效.<br /> <br /> ===结节性硬化症长期误诊为癫痫1例并文献复习===<br /> 结论 [[雷帕霉素]]治疗以癫痫为首发表现的[[结节性硬化症]],疗效确切.<br /> <br /> ===雷帕霉素对儿童结节性硬化症相关肾脏疾病的疗效观察===<br /> [[雷帕霉素]]对儿童[[结节性硬化症]]相关肾脏疾病的疗效观察<br /> <br /> ===雷帕霉素对儿童结节性硬化症相关肾脏疾病的疗效观察===<br /> 目的 探讨[[雷帕霉素]]治疗[[结节性硬化症]](TSC)相关肾脏疾病患儿的疗效和安全性.<br /> <br /> ===雷帕霉素治疗结节性硬化症合并室管膜下巨细胞型星形细胞瘤四例报告及文献复习===<br /> [[雷帕霉素]]治疗[[结节性硬化症]]合并室管膜下巨细胞型星形细胞瘤四例报告及文献复习</div>

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