http://120.24.161.253:5617/index.php?action=history&feed=atom&title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3 2026-04-16T20:31:27Z 本wiki的该页面的版本历史 MediaWiki 1.30.0 http://120.24.161.253:5617/index.php?title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3&diff=2020118&oldid=prev 2026-04-15T13:34:42Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="1" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: white; color:black; text-align: center;">2026年4月15日 (三) 13:34的版本</td> </tr><tr><td colspan="2" style="text-align: center;" lang="zh-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

KGadmin http://120.24.161.253:5617/index.php?title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3&diff=2020117&oldid=prev 2026-04-13T13:56:59Z

<p>修改1</p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2026年4月13日 (一) 13:56的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >第1行：</td> <td colspan="2" class="diff-lineno">第1行：</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>主实体：[[帕金森病]]，关系：[[药物治疗]] ，尾实体：[[利福平]]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>主实体：[[帕金森病]]，关系：[[药物治疗]] ，尾实体：[[利福平]]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">实体ID:''1411035''</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==关系介绍==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==关系介绍==</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>待补充</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>待补充</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==来源==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===利福平抑制α-synuclein的聚集及对MPP+<del class="diffchange diffchange-inline">诱导细胞损伤的拮抗作用（中华医学会文献）</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===利福平抑制α-synuclein的聚集及对MPP+<ins class="diffchange diffchange-inline">诱导细胞损伤的拮抗作用</ins>===</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>目的:探讨[[利福平]]对[[帕金森病]]致病蛋白α-突触共核蛋白(α-synuclein)聚集的影响,以及对1-甲基-4-苯基-吡啶离子(MPP+)诱导的细胞损伤的拮抗作用.</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>目的:探讨[[利福平]]对[[帕金森病]]致病蛋白α-突触共核蛋白(α-synuclein)聚集的影响,以及对1-甲基-4-苯基-吡啶离子(MPP+)诱导的细胞损伤的拮抗作用.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">利福平对鱼藤酮处理的大鼠多巴胺神经元的保护作用（中华医学会文献）</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">利福平抑制α-synuclein的聚集及对MPP+诱导细胞损伤的拮抗作用===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">方法:选用大鼠嗜铬细胞瘤株PC12细胞,利用MPP+诱导建立[[帕金森病]]细胞模型,[[利福平]]进行干预;采用MTT法检测细胞活性、Western blotting法检测α-synuclein表达及聚集,流式细胞仪检测细胞凋亡.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===利福平对鱼藤酮处理的大鼠多巴胺神经元的保护作用</ins>===</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>目的:观察[[利福平]]对鱼藤酮诱导[[帕金森病]]大鼠模型多巴胺神经元的保护作用以及对突触核蛋白形成和聚集的抑制作用.</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>目的:观察[[利福平]]对鱼藤酮诱导[[帕金森病]]大鼠模型多巴胺神经元的保护作用以及对突触核蛋白形成和聚集的抑制作用.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">利福平预处理通过Nrf2减轻帕金森病小胶质细胞的氧化损伤（中华医学会文献）</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">利福平对鱼藤酮处理的大鼠多巴胺神经元的保护作用===</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">测以证明[[利福平]]对[[帕金森病]]动物模型多巴胺神经元具有保护作用,对突触核蛋白的形成和聚集具有抑制作用.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===利福平预处理通过Nrf2减轻帕金森病小胶质细胞的氧化损伤</ins>===</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>[[利福平]]预处理通过Nrf2减轻[[帕金森病]]小胶质细胞的氧化损伤</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>[[利福平]]预处理通过Nrf2减轻[[帕金森病]]小胶质细胞的氧化损伤</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>===<del class="diffchange diffchange-inline">利福平通过促进自噬保护帕金森病模型细胞损伤（中华医学会文献）</del>===</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>===<ins class="diffchange diffchange-inline">利福平预处理通过Nrf2减轻帕金森病小胶质细胞的氧化损伤</ins>===</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[<del class="diffchange diffchange-inline">利福平</del>]]<del class="diffchange diffchange-inline">通过促进自噬保护</del>[[<del class="diffchange diffchange-inline">帕金森病</del>]]<del class="diffchange diffchange-inline">模型细胞损伤</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[<ins class="diffchange diffchange-inline">方法]利用鱼藤酮刺激的BV2小胶质细胞建立</ins>[<ins class="diffchange diffchange-inline">[帕金森病</ins>]]<ins class="diffchange diffchange-inline">氧化应激的模型,分别用不同浓度的</ins>[[<ins class="diffchange diffchange-inline">利福平</ins>]]<ins class="diffchange diffchange-inline">预处理BV2小胶质细胞,CCK-8法检测细胞存活率;分别用双氯荧光素(DCFH-DA)、罗丹明123染色后使用流式细胞仪检测活性氧(ROS)水平和线粒体膜电位(MMP</ins></div></td></tr> </table>

Admin http://120.24.161.253:5617/index.php?title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3&diff=1129255&oldid=prev 2024-07-06T14:00:00Z

<p>修改1</p> <table class="diff diff-contentalign-left" data-mw="interface"> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="1" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: white; color:black; text-align: center;">2024年7月6日 (六) 14:00的版本</td> </tr><tr><td colspan="2" style="text-align: center;" lang="zh-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

Admin http://120.24.161.253:5617/index.php?title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3&diff=1129256&oldid=prev 2024-07-06T08:56:31Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="1" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: white; color:black; text-align: center;">2024年7月6日 (六) 08:56的版本</td> </tr><tr><td colspan="2" style="text-align: center;" lang="zh-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

KGadmin http://120.24.161.253:5617/index.php?title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3&diff=258655&oldid=prev 2021-10-21T08:00:47Z

<p>导入1个版本</p> <table class="diff diff-contentalign-left" data-mw="interface"> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="1" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: white; color:black; text-align: center;">2021年10月21日 (四) 08:00的版本</td> </tr><tr><td colspan="2" style="text-align: center;" lang="zh-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

Admin http://120.24.161.253:5617/index.php?title=%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85-%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97-%E5%88%A9%E7%A6%8F%E5%B9%B3&diff=258652&oldid=prev 2021-10-19T13:56:59Z

<p>修改1</p> <p><b>新页面</b></p><div>主实体：[[帕金森病]]，关系：[[药物治疗]] ，尾实体：[[利福平]]<br /> <br /> 实体ID:''1411035''<br /> ==关系介绍==<br /> 待补充<br /> <br /> ==来源==<br /> ===利福平抑制α-synuclein的聚集及对MPP+诱导细胞损伤的拮抗作用（中华医学会文献）===<br /> 目的:探讨[[利福平]]对[[帕金森病]]致病蛋白α-突触共核蛋白(α-synuclein)聚集的影响,以及对1-甲基-4-苯基-吡啶离子(MPP+)诱导的细胞损伤的拮抗作用.<br /> <br /> ===利福平对鱼藤酮处理的大鼠多巴胺神经元的保护作用（中华医学会文献）===<br /> 目的:观察[[利福平]]对鱼藤酮诱导[[帕金森病]]大鼠模型多巴胺神经元的保护作用以及对突触核蛋白形成和聚集的抑制作用.<br /> <br /> ===利福平预处理通过Nrf2减轻帕金森病小胶质细胞的氧化损伤（中华医学会文献）===<br /> [[利福平]]预处理通过Nrf2减轻[[帕金森病]]小胶质细胞的氧化损伤<br /> <br /> ===利福平通过促进自噬保护帕金森病模型细胞损伤（中华医学会文献）===<br /> [[利福平]]通过促进自噬保护[[帕金森病]]模型细胞损伤</div>

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